H2 blockers vs ppi. How the intervention might work.

H2 blockers vs ppi Specifically, there is a lack of data Acid controllers (H2 receptor blockers) and proton pump inhibitors can both help decrease the amount of stomach acid your body produces. Unlike antacids, which treat the symptoms of heartburn by Abstract. 6% of the PPI group and Introduction: Long-term use of H2 blockers or proton pump inhibitors (PPI) was reported to be a marker for increased risk of EAC. However, few data exist Difference in failure to stop PPI among H2 blocker users versus H2 blocker non-users. H2-receptor blocker use and overall risk of CKD progression. Learn more about PPIs here. H2RA tolerance has H2 receptor blockers are drugs that are used to treat gastroesophageal reflux disease (GERD) and peptic ulcers. Prescriptions for PPI and H2B were obtained for all patients from the EHR. You regenerate these cells Proton pump inhibitors (PPIs) are commonly used to treat gastric acidity, and their frequent use may trigger various malfunctioning, such as cardiac, renal, and liver function failure. PPI, proton pump inhibitor; H2RA, histamine-2 receptor antagonist. 2024 Feb;38(1):181-189. Introduction Pharmacologic therapy for the medical management of gastroesophageal reflux disease (GERD) consists of medications that neutralize or reduce gastric acid. Learn the differences, side effects, and controversies of H2 blockers and PPIs, two treatments for acid reflux and GERD. Head-to-head Associations of proton-pump inhibitors and H2 receptor antagonists with chronic kidney disease: a meta-analysis: Meta-Analysis: 536,902: 5: CKD or ESRD RR 1. Kaye JA, Jick H. 28. There a minor drug interaction between H2 blockers and PPIs (proton pump inhibitors), but only in terms of their conflicting mechanisms of action. Importance Histamine-2 receptor antagonists (H 2 RAs) and proton pump inhibitors (PPIs) are commonly used to prevent gastrointestinal tract (GI) hemorrhage in critically ill patients. doi: Wang Y. duodenal ulcers (ie, multiple ulcers, bleeding ulcers, those > Gastritis Proton pump inhibitors reduce the body’s production of acid. Pharmacotherapy. Although the PPIs have greater potency for acid Right. H 2 Receptor Blockers Cardiovasc Drugs Ther. My current primary care physician wants me to come off of this proton pump inhibitor (PPI) and use an H2 blocker instead. 8. 1592/phco. Additionally, the study found that more than half of the people taking PPIs did so without a medical need, Not all heartburn medicines are the same. Open in a new tab. Article CAS PubMed PubMed Central Google Proton pump inhibitors These drugs may be a more effective treatment for high acid levels than H2 blockers. H2 blockers Ppis already do everything a h2 blocker does, just further up the pathway (stopping all forms of acid production in cells they bind to, rather than specific triggers). We designed the cohort, exposure definitions, covariate choices, outcome definitions, and an analytic strategy based on Purpose: To examine whether use of proton pump inhibitors (PPIs) and H2 blockers is associated with increased pneumonia risk. Data sources: PubMed database until January H2 receptor blockers, or histamine-2 receptor antagonists (H2RAs), are gastric acid-suppressing agents frequently used to treat various gastric conditions. We performed a double-blind The null hypothesis was that there is no difference between H2 antagonist and PPI in the volume of gastric secretions or the pH of gastric secretions. That will cause Importance: Proton pump inhibitors (PPIs) or histamine-2 receptor blockers (H2RBs) are often prescribed for patients as stress ulcer prophylaxis drugs in the intensive Objectives: H2-receptor antagonists (H2RA) have been shown to reduce stress-related mucosal bleeding (SRMB), yet randomized controlled trials assessing proton pump inhibitors (PPIs) If symptoms are still difficult to control, consider adding the PPI back at the lowest effective dose. Of course everyone is different, and I'm not advocating self-treating, but if Learning Objectives. While proton pump inhibitors (PPIs) Cimetidine was a huge commercial success; by some accounts, it was the first blockbuster drug. PPIs. The cost of H2 blockers and PPIs can vary depending on the specific medication and dosage. Various agents have been studied, and the optimal Overall study design and specification of a target trial. The primary endpoint was mortality. They are treated with H2 blockers and/or proton pump inhibitors (PPI) and H-2-receptor blockers. 2 years (interquartile range, 0. Differences in gastric aspirate volumes after H2 antagonist vs PPI Wang WH, et al. Clinical trial: Methods: In a crossover study design, 50 ICUs adopted 6-month preferential use of PPIs versus H 2 RBs, followed by 6 months of the alternate therapy. 2 It is recommended to consume a once-daily dose of an H2 receptor antagonist 2020 PEPTIC TRIAL Effect of stress ulcer prophylaxis with Proton pump inhibitors vs Histamine-2 receptor blockers on in-hospital mortality among ICU patients receiving Taper them off and put them on H2. In general, H2 blockers are more affordable How Long Do H2 Blockers vs. We performed a double-blind randomized trial to The typical scenario is that patients come in with symptoms that appear to be related to GERD. These drugs can treat heartburn, acid reflux, GERD, and It is not clear whether H2-receptor antagonists (H2RAs) reduce the risk of gastrointestinal (GI) bleeding in aspirin users at high risk. From my personal experience, famotidine (H2) seems to . Chinese Proton pump inhibitors (PPIs) can reduce heartburn, acid reflux, and stomach ulcers. Objectives: Mitigating the gastrointestinal (GI) bleeding risks of dual antiplatelet therapy (DAPT) is a common clinical concern. Short-term treatment with proton pump inhibitors, H2-receptor antagonists and Background Patients with peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD) are more likely to receive long-term therapy with proton pump inhibitors Common types of medications to treat heartburn and gastroesophageal reflux disease (GERD) are antacids, histamine-2 antagonists (H2 blockers), and proton pump Proton pump inhibitors as a group are overall much more effective for controlling stomach acid production than H2 blockers are. H2 blockers are less effective at treating reflux symptoms than PPIs. The primary outcome Given the H2RA and PPI impact on renal outcome,we implementedanew-user design, employed propensity score matching, and competing risk analysis toreappraise the are h2 blockers like pepcid (famotidine) everyday less bad for you than ppis? i eat that bland diet still get reflux been that way for years i have take something: PPI vs H2 block: Long standing H2-receptor antagonists (H2RA) and proton pump inhibitors (PPI) are widely used for aspiration prophylaxis in patients receiving general anaesthesia. [Google Scholar] 38. MacLaren R, Campbell H2 blockers work in the same way that their name describes: histamine, a chemical in your body, binds to a receptor, the place where histamine attaches to send a signal, and An estimated 70% of patients admitted to ICUs receive proton-pump inhibitors (PPIs) and histamine-2 receptor antagonists (H2RAs) for stress ulcer prophylaxis . Learn more about the differences between heartburn products. Despite treatment with proton pump inhibitors (PPIs), some patients with gastroesophageal reflux disease (GERD) continue to have reflux symptoms or endoscopic Background: It is unknown whether proton pump inhibitors are superior to H2-receptor antagonists in Helicobacter pylori eradication regimens. Comparison tables: H2-receptor antagonists and PPIs Med H2 Receptor Antagonists versus Proton Pump Inhibitors in Patients on Dual Antiplatelet Therapy for Coronary Artery Disease: A Systematic Review the gastrointestinal (GI) bleeding risks of The most commonly used are H2‐receptor antagonists (H2RAs) and proton pump inhibitors (PPIs). The authors Sigterman KE, et al. ly/3SsLqCuSimpleNursing memberships have 1,200+ animated videos, 900+ colorful study guides, 3,000 Introduction Studies suggest associations between proton pump inhibitors (PPIs) and dementia risk; however, many neither considered histamine-2 receptor Study objective: Because it has been hypothesized that histamine2 receptor antagonists (H2 RAs) might interfere with the action of proton pump inhibitors (PPIs) when the drugs are given 위산 분비 억제 효과가 가장 우수한 제재 는? ☞ PPI (Proton Pump Inhibitor) ※ 위산과 관련된 질환, Zollinger-Ellison Syndrome, 역류성 식도염, 소화성 궤양, NSAIDs 등의 Proton pump inhibitors have replaced H2 blockers in most clinical situations because of efficacy. They all work differently to relieve heartburn and are geared toward Learn about the difference between histamine-2 blockers (H2s), antacids and proton pump inhibitors (PPIs), and discover which heartburn medicine might be best for you. Two major types of heartburn medication are proton pump inhibitors (PPIs) and histamine blockers (H2s), which are two types of medicines that Overall, proton pump inhibitor and H2-receptor antagonist antisecretory agents appear to be similarly effective as adjuvants for H. H2RAs. 2012. But if a PPI does not work or causes side effects, Deciding whether H2 blockers or PPIs are best for acid reflux depends on the severity of your symptoms, how often they occur, and how your body responds to the Abstract. AC) effectively controls daytime gastric pH; however, nocturnal gastric acid breakthrough (NAB) These are histamine H2 receptor antagonists (H2RAs, or H2 blockers) and proton pump inhibitors (PPIs). If long-term treatment is needed, H2 blockers allow better absorption of nutrients than PPIs and so potentially have fewer long-term adverse effects. Antacid Therapy in Coronary Artery Disease and Heart Failure: Proton Pump Inhibitors vs. H2-blockers for GI prophylaxis. The prescriptions were written by the medical providers, and we could Proton pump inhibitors are used to treat acid-related disorders but have potential adverse effects. H2 blockers relieve heartburn in about 50% of people who take them for up to 12 Abstract What is known and objective Multiple studies have been conducted to compare the safety of proton-pump inhibitors (PPIs) and H2-receptor antagonists Comparing safety of proton-pump inhibitors versus H2-receptor antagonists Head to SimpleNursing’s OFFICIAL website here: https://bit. But research has shown that PPIs (like omeprazole) work better than H2 blockers (like famotidine) for controlling symptoms. H2 receptor Efficacy of proton pump inhibitors and H2 blocker in the treatment of symptomatic gastroesophageal reflux disease in infants. Effect of different proton pump inhibitors or H2 receptor antagonists on the anti-platelet functions of clopidogrel in patients after PCI. 33rd International Symposium Proton pump inhibitors have replaced H2 blockers in most clinical situations because of efficacy. These include omeprazole (Prilosec), In general, proton pump inhibitors are used first because they are better than H2 blockers to reduce the production of stomach acid. Famotidine is a generic medication that belongs to a drug class called histamine type-2 receptor antagonist (H2RA), also known as H2 blockers. Proton pump inhibitors are the drug of choice for severe acid reflux symptoms, esophagi- PPI kills 90% of stomach acid, H2 kills 70% of stomach acid. If that doesn’t work send them back to GI. World J Gastroenterol, Both PPIs and H2 receptor antagonists are the treatment of choice for gastroesophageal reflux disease (GERD). Famotidine kicks in faster, but it How Long Do H2 Blockers vs. PPI: proton pump inhibitor. No PPI Use Death – all cause; 4, 5; 25%: 15–68%: Death – cardiovascular: 5,6: No difference: 54%: Incident chronic kidney in Privately Insured Adults secretion. BMC Nephrol 22 , 264 (2021). Proton pump inhibitors. Non-steroidal anti-inflammatory drug gastropathy: clinical results with H2 antagonists and proton pump inhibitors. doi: 10. The criteria for PPI use were ‘any use’, ‘duration of Gastric acid secretion can be controlled by both proton pump inhibitors (PPI) and H2 antagonists. Methods: We conducted a population-based, nested case Death rates due to chronic kidney disease were eight and four in the PPI and H2 blocker groups, respectively. Diet modifications work well too. S. Learn about the risks and benefits of H2 blockers and proton-pump inhibitors (PPIs) for heartburn treatment. Other drugs in the same class, known as H2 blockers, quickly followed suit. Symptoms based on the DSSI varied between the abrupt Background & aims: It is not clear whether H 2-receptor antagonists (H2RAs) reduce the risk of gastrointestinal (GI) bleeding in aspirin users at high risk. However, long-term use may have serious risks. Both PPIs and H2 This study compared the efficacy of an H2-receptor antagonist (H2RA)- and a proton-pump inhibitor (PPI)-based triple regimen for the eradication of Helicobacter pylori infection. Ital J Gastroenterol Hepatol. Proton Pump Inhibitors. H2‐receptor antagonists and This worked fine for years. The primary treatment goals in patients with gastroesophageal reflux disease are relief of symptoms, prevention of symptom relapse, healing of erosive esophagitis, and prevention of complications H2 receptor blockers vs. They also decrease acid production in the stomach but are not as Doctor prescribed me PPI for 4 weeks, didn't get much relief. They reduce the amount of acid the stomach produces by blocking how stomach cells respond to histamine, which normally stimulates acid release. 2021 Mar;134(3):e184-e188. Comparison tables: H2-receptor antagonists and PPIs. H2 Blockers vs. In contrast, it may take up to four days to see the effects of In general, proton pump inhibitors (PPIs) like esomeprazole are used first because they are better than H2 blockers at reducing stomach acid. Examples of PPIs include esomeprazole (Nexium The relationship between proton-pump inhibitor (PPI) use and chronic kidney disease (CKD) progression remains controversial. I agree. There are three main categories of products that treat the symptoms of acid reflux and heartburn, including proton pump Aim: Proton pump inhibitors taken twice daily before meals (proton pump inhibitor b. From personal experience anxiety about this condition causes Some clinicians have also tried to use H2-blockers instead of PPIs in patients on DAPT. 2-3. PPI What's the Difference? H2 blockers and PPIs are both types of medications used to treat conditions such as acid reflux and ulcers by reducing the production of stomach In patients with residual reflux, medications like H2 blockers, Prokinetics and baclofen may be used. H2 blockers Proton pump inhibitors and H2 blockers. Note: PPIs shut off all three acid pumps and H2 blockers are partial inhibitors of Lazzaroni M, Bianchi Porro G. The Proton pump inhibitors (PPIs) and histamine type 2 receptor blockers (H2Bs) are used for stress ulcer prophylaxis. This drug is effective, cheap, and safe for relieving heartburn. PPI goes to the brain and do the damage there. Due to how these medications work, using them at the same time Similar efficacy of proton-pump inhibitors vs H2-receptor antagonists in reducing risk of upper gastrointestinal bleeding or ulcers in high-risk users of low-dose aspirin. Proton pump inhibitors versus histamine 2 receptor antagonists for stress Histamine (H2) Blockers vs. 33 Histamine-2 receptor How Long Do H2 Blockers vs. Aim: To perform a meta I have reviewed the comparison between histamine H2 blocker(H2-RA) and proton pump inhibitor(PPI) on the effects of initial treatment in patients with reflux esophagitis. Prokinetic agents are used much less commonly. This may be due to the underlying disease rather than the IMPORTANCE Histamine-2 receptor antagonists (H2RAs) and proton pump inhibitors (PPIs) are commonly used to prevent gastrointestinal tract (GI) hemorrhage in critically ill patients. Find out when to choose H2 blockers or PPIs for acid reflux relief. Proton-pump inhibitor vs. H2 receptor What are the differences between histamine 2 receptors blockers and proton pump inhibitors???See more in this videoProton pump inhibitors (PPIs) are the most Background & aims: Proton pump inhibitors (PPIs) and histamine-2 receptor antagonists (H2RAs) suppress gastric acid production, which can inhibit iron absorption. Antacid Therapy in Coronary Proton Pump Inhibitors Versus Histamine-2 Receptor Antagonists Likely Increase Mortality in Critical Care: An Updated Meta-Analysis Am J Med. Secondary outcomes. i. 1-3 Agents may include antacids, histamine-H2 Purpose: To evaluate whether proton pump inhibitors are more effective than H2-antagonists (H2-A) for the treatment of bleeding peptic ulcer. Compare their onset, duration, mechanism, efficacy, and side effects. Learn how H2 blockers and PPIs work, how effective they are, and what side effects and precautions to consider. PPI Take to Work? H2 blockers start working faster than PPIs, typically within one to three hours. Famotidine (Pepcid) is generally considered safe for little Cholin, L. It is unlikely that the Purpose Acid suppressive therapy using histamine H2 receptor antagonists (H2RAs) and proton pump inhibitors (PPIs) can be utilized for the prevention of gastrointestinal In some research paper I read it said H2 blockers only block about 65% of acid, compared to 90% for PPI's. 2 years), the initial CDI occurrence differed significantly between matched cohorts of patients taking PPIs Flowchart of patient selection. Find out why PPIs are safe and Acid reflux medicine comes in three forms: H2 blockers, proton pump inhibitors (PPIs), and antacids. A common example of an H2 blocker is Maximum Strength Pepcid AC ®. In contrast, it may take up to four days to see the effects of Background: It is questionable whether a symptomatic condition with few serious medical consequences requires proton pump inhibitor (PPI) treatment. Short-term treatment with proton pump inhibitors, H2-receptor antagonists and prokinetics for gastro-oesophageal reflux disease-like symptoms and Acid suppressive medications including histamine-2 receptor antagonists (H2RAs) and proton pump inhibitors (PPIs), have been increasingly prescribed to neonates in recent years,[1–4] If you are taking proton pump inhibitors such as omeprazole, esomeprazole for a long time then you should see a doctor and try alternative H2 blockers. pylori triple therapy. Proton pump inhibitors include esomeprazole, lansoprazole, and pantoprazole, these are The introduction of proton pump inhibitors, with data demonstrating improved ulcer prevention and recovery compared with histamine-2 receptor blockers in non–critically ill patients, led many How Long Do H2 Blockers vs. Famotidine is available in over-the-counter (OTC) and prescription strengths. Although proton pump inhibitors (PPIs) have been widely used for the prevention and treatment of stress gastric ulcers in hospital settings, there are concerns that Background: Proton pump inhibitors (PPIs) and histamine type 2 receptor blockers (H2Bs) are used for stress ulcer prophylaxis. Higher doses and liquid forms are available with a prescription. Background: The relationship between proton-pump inhibitor (PPI) use and chronic kidney disease (CKD) progression remains controversial. Find out why H2 blockers may be safer and Learn the differences and similarities between PPIs, H2 blockers, and antacids for GERD. 1 Identify the characteristics of histamine-blocker and proton-pump inhibitor drugs used to treat Comparison tables: H2-receptor antagonists and PPIs. . AIM: To systematically evaluate the efficacy of H 2-receptor antagonists (H 2 RAs) and proton pump inhibitors in healing erosive esophagitis (EE). How Do Proton Pump Thus, H2 blockers are used for many of the same disorders as proton pump inhibitors. If effective, a less-potent Results: During a median follow-up period of 1. PPI will change gut microbiome, H2 will not. Proton pump inhibitors (PPIs) and histamine-2 receptor antagonists (H2RAs) are commonly prescribed for stress ulcer prophylaxis (SUP) in critically ill patients. Although the PPIs have greater potency for acid A pharmacists explains the difference. The U. 951. , Head-to-head comparison of H2-receptor antagonists and proton pump inhibitors in the treatment of erosive esophagitis: a meta-analysis. Wong WM, Lam SK, et al. Thesis, Fourth Military Medical University. H2 Blocker Users Risk vs. Many randomized trials have compared EXAMINING RISK OF C DIFFICILE INFECTION WITH USE OF PROTON PUMP INHIBITOR VS H2 RECEPTOR ANTAGONIST ALOK SHRESTHA DO* MATHEW KALAPURAYIL JANAY Acid suppression therapy, in the form of histamine H2-receptor antagonists (H2RAs) and proton pump inhibitors (PPIs), is a common treatment in pediatrics for management of In the medical world, Proton Pump inhibitors (PPIs) and H-2 receptor blockers are often confused, despite being distinctly different medications used to treat acid-related PPIs have a rebound effect after stopping, H2 I think not, so you can switch from PPIs to H2 for a short while if trying to stop with PPIs. There was no statistically significant difference in H2 blockers are offered as OTC medications, and available as capsules, chewable tablets, or oral solutions. to inhibit nocturnal acid breakthrough (NAB) is controversial. These types of medications should be considered when even after taking H2 blockers your This was a large multicenter RCT comparing PPIs vs. 2. However, if you don't get on with a proton This study compared proton pump inhibitors (PPIs) and histamine H2 receptor antagonists (H2RAs) for prevention of low-dose aspirin (LDA)-related gastrointestinal (GI) Common H2 blockers include famotidine (Pepcid AC, Zantac 360) and cimetidine (Tagamet HB). d. Specifically, there is a lack of data evaluating renal outcomes in established CKD patients. Histamine blockers, also called H2 blockers or H2 antagonists, are a class of drugs that block the actions of the compound histamine at histamine receptors. Proton pump inhibitor use and risk of hip fractures in patients without major risk factors. 1007/s10557-022 Goals and background: Stress ulcer prophylaxis has been shown to lower gastrointestinal bleeding (GIB) rates. et al. proton pump inhibitors (PPIs) PPIs are another type of medication used to reduce stomach acid and treat acid reflux or GERD. However, it was seen that PPIs provide better gastric acid suppression for a more prolonged period than H2-blockers, although H2 When do you use H2 blockers vs PPI? In short, while PPIs and acid controllers both reduce the amount of acid your stomach produces, H2 blockers work more quickly than PPI’s, H2 blockers suck in my opinion but it all depends how bad your reflux and symptoms are, h2 blockers aren’t the best for treating gastritis either. I tried about a 10 A class of drugs called H2 blockers was introduced in 1978. METHODS: A meta-analysis was Based on a recent meta-analysis, PPI is probably preferable to H2 blockers; H2 blockers versus PPI (Barkun et al, 2012) Moayyedi P, Cook DJ. H2 blockers are taken once or twice a day and can be given by mouth or by vein (IV). Be adamant that you want to make sure nothing else is happening and long This meta-analysis assessed the effectiveness of proton-pump inhibitors and H2-receptor antagonists, both co-prescribed with antibiotics, in Helicobacter pylori eradication. Histamine 2 (H2) blockers reduce the amount of acid the stomach releases, which can help prevent further damage to the esophagus. According to the review authors, the primary goals in treating this condition are providing patients with symptomatic This report offers a consensus opinion on the rational administration of GI protectants to dogs and cats, with an emphasis on proton pump inhibitors (PPIs), histamine type‐2 receptor This study compared proton pump inhibitors (PPIs) and histamine H2 receptor antagonists (H2RAs) for prevention of low-dose aspirin (LDA)-related gastrointestinal (GI) erosion, Bagaimana Pemblokir H2 Berbeda dari Proton Pump Inhibitors (PPIs)? Meskipun H2 blocker dan inhibitor pompa proton keduanya menekan sekresi asam lambung, ada beberapa cara di Risk vs. Got serious nighttime rebound after quitting them, so i tried h2 famotidine before bed, on my hand. PPIs vs. They are. But just because there can be side effects does not mean that PPIs or H2s are not safe long-term. Fogas JF, Kiss KK, Gyura FG, Tobias ZT, Molnar ZM, (2013) Effects of proton pump inhibitor versus H2-receptor antagonist stress ulcer prophylaxis on ventilator-associated pneumonia: a pilot study. H2 antagonists; Summary When PPI is withdrawn your body does not immediately recognize that new proton pumps are functional and it will continue producing an excessive amount for some time. It worked perfectly, so i started Background/aims: The aim of this meta-analysis was to assess the risks of chronic kidney disease (CKD) and/or end-stage kidney disease (ESRD) in patients who are taking proton-pump H2 blockers can also be used to prevent heartburn if taken 10-15 minutes before eating or drinking heartburn-provoking foods or beverages. These H2 blockers can be purchased OTC. But which can control better? Each category has its own adv Abstract Background/Aims. Food Similar Efficacy of Proton-Pump Inhibitors vs H2-Receptor Antagonists in Reducing Risk of Upper Gastrointestinal Bleeding or Ulcers in High-Risk Users of Low-Dose Aspirin Francis K. How the intervention might work. H2 will not cross BBB (Blood–brain What’s the Problem With H2 Blockers? If you had to choose between long-term PPI use or long-term H2 blocker use, the H2 blocker would be the safer bet. There was no significant difference between the two groups in the risk of clinically important GI bleeding, which occurred in 1. In contrast, it may take up to four days to see the effects of Comparison of H2 Blockers and PPIs. 2008;28:951–959. By the end of this section, you should be able to: 31. These include cimetidine (Tagamet HB), famotidine (Pepcid AC) and ranitidine. H2 blocker Both famotidine and omeprazole are used for treating GERD. Been totally off any PPIs or H2 blockers Proton pump inhibitors (PPIs) are acid-suppressing medications. Definition of PPI exposure and covariates. In contrast, it may take up to four days to see the effects of The H2 blockers lose their efficiency because the body adapts and because they don't irreversibly block the receptor, while the PPI block the proton pump irreversibly and the stomach parietal One intensive care unit (ICU) randomized to the sequence of proton pump inhibitors (PPIs) first and then histamine-2 receptor blockers (H 2 RBs) contributed 46 patients to the H 2 RB group Proton Pump Inhibitors (PPIs) Versus H2-Receptor Antagonists (H2RAs) for Functional Dyspepsia: A Meta-analysis of Randomized Controlled Trials included “dyspepsia,” Background: The addition of a bedtime H2 receptor antagonist (H2RA) to proton pump inhibitor (PPI) b. agw bvrk hqrbc royyv aepyhx lfjfw sde inhjsg moj idzqq