Mifepristone birth defects. Mifepristone works by blocking the hormone progesterone.

If you have an ongoing pregnancy after using Misoprostol, the risk of having a baby with fetal malformations is increased. According to testimony from the inventor of the abortion pill reversal method, the profitable abortion industry has used the scare tactic of birth defects to pressure women into going ahead to continue their pregnancies. The Supreme Court upheld access to a widely available abortion pill, rejecting a bid from a group of anti-abortion organizations and doctors to unravel the Food Jul 25, 1998 · Claudette Gonzalez and colleagues (May 30, p 1624)1 describe birth defects after failed illegal abortion in 42 infants who were exposed to misoprostol at doses of 200–1600 μg during the first 3 months of gestation. Talk with your doctor about your treatment options. Mifepristone (Mifeprex) is taken along with misoprostol (Cytotec). Mifepristone became widely available in 2000, creating a safe and simple way to terminate a pregnancy up to the 10th week without having a surgical abortion. See also Warning section. Better known as the abortion pill or Mifeprex (mifepristone), RU486 is only available with a prescription. Both mifepristone and misoprostol can cause birth defects if you are still pregnant. It causes the uterus to contract This article reports a case series of 261 women who attempted to reverse the effects of mifepristone, a drug used for medical abortion, by using progesterone. It is possible to continue bleeding for up to 30 days. A medical abortion (also called a medication abortion) uses doctor-prescribed drugs to end an early pregnancy. Moreover, as Grossman noted, the prescription of an unproven treatment to pregnant women has Nov 9, 2023 · Neither progesterone nor mifepristone have been associated with birth defects . It blocks the effects of progesterone, a natural sex hormone that's important in starting and continuing a pregnancy. Jun 25, 1998 · The mean age at the time of the diagnosis of Möbius' syndrome was 16 months (range, 0. Oral route (Tablet) Misoprostol administration to women who are pregnant can cause birth defects, abortion, premature birth, or uterine rupture. Systematic review registration: PROSPERO, CRD42022302626. Mifeprex may cause birth defects in an unborn baby if the treatment procedure does not fully terminate the pregnancy. 3%). There thus appears to be no increased risk of birth defects, according to Delgado, for babies born after mifepristone reversal. You and your provider should discuss the benefits and risks of your using Mifeprex. What Mifegyne looks like and contents of the pack. At 9-10 weeks pregnant, it works about 91-93% of The chance of birth defects if the pregnancy is not ended is unknown. Birth defects related to misoprostol exposure in pregnancy are poor growth of limbs (missing parts of finger/toes, or parts of arms/legs), Moebius syndrome (weakness or paralysis of the facial muscles), cleft lip and/or cleft palate (lip and or roof of mouth formed with a split), arthrogryposis (stiff joints), muscle weakness, and club foot that do not restrict telehealth for medication abortion, mifepristone can be sent via mail. Obstetrician-gynecologists should be familiar with its pharmacology and applications in practice. , uterine contraction and bleeding) could Jan 24, 2013 · A total of 105 pregnancies were included, with 46 exposed to mifepristone alone, and 59 exposed to both mifepristone and misoprostol. As a The pioneer of sociology of scientific knowledge, Ludwik Fleck, argued that the strong belief that syphilis equals “bad blood” stimulated a tenacious quest for a serological test for this disease. Bleeding and spotting are normal side effects of Mifeprex and misoprostol. Neither malformation was thought to be related to mifepristone exposure but may have been a result of other medical conditions (Bernard et al. Enhanced monitoring of fetal viability, growth and development is indicated in ongoing pregnancies exposed to Sep 5, 2022 · The first, mifepristone, blocks progesterone, a hormone necessary for pregnancy. This report underscores both the risk of misuse of misoprostol used as a sole agent to procure abortion and the social consequences of the restrictive laws on abortion in Brazil. Before you take Mifeprex, you should read this MEDICATION GUIDE and sign a statement (PATIENT AGREEMENT). (4) Malformations, including one case of Möbius syndrome, have been reported in France after medically supervised use of misoprostol. g. See medically reviewed information on Mifepristone. according to the Guttmacher Institute, which researches reproductive procedure to end your pregnancy. Due to its uterotonic properties, it is also indicated in obstetrics for induction of labor and termination of pregnancy. In the early weeks of pregnancy, the fetus pain sensory receptors are quickly developing, and the baby’s capability of experiencing pain increases as the pregnancy progresses. Share full article. You may need surgery to end the pregnancy completely. Jul 13, 2023 · The Abortion Pill Rescue Network is backed by Heartbeat International, an anti-abortion group that supports a large network of crisis pregnancy centers. It was expected that a number of participants would experience bleeding and/or cramping, since these are commonly experienced after mifepristone ingestion or in miscarriage . 4%) and 10 (9. Exposure of fetuses to Misoprostol can lead to malformations, such as defects in the skull and abnormalities in the limbs and nervous system (called Mobius Syndrome). Mifegyne is available in pack sizes o. Exclusion criteria were requests received after 22 Dec 8, 2021 · Mifepristone was first marketed in Canada in January 2017 as a 200-mg tablet combined with 800 μg of misoprostol. Mifeprex is the first drug developed in a class of drugs called “selective progesterone receptor blockers”. There was no apparent increased risk of birth defects. (1) (2) Failure is a well-known complication of medical abortion. Before you take Mifepristone tablets, 200 mg you should read this Medication Guide and you and your healthcare provider should discuss the benefits and risks of your using Mifepristone tablets, 200 mg. Neither mifepristone nor progesterone are associated with birth defects according to The American Academy of Obstetricians and Gynecologists. Introduction Medical induced abortion utilizing mifepristone has been available in the Unit-ed States since 2000. (5) In practice, when a patient wishes to continue a pregnancy Birth defects have been reported with a continued pregnancy after a failed pregnancy termination with MIFEPREX in a regimen with misoprostol. There was no major hemorrhage or other clinically significant adverse events in the PAMper Mar 30, 2023 · Birth defects have been reported with a continued pregnancy after a failed pregnancy termination with Mifepristone tablets, 200 mg in a regimen with misoprostol. May 29, 2024 · Available data limited to exposure following a single dose of mifepristone during pregnancy showed a higher rate of major birth defects compared to the general population comparator (See Data). A failed pregnancy termination could cause birth defects. Available data limited to exposure following a single dose of mifepristone during pregnancy showed a higher rate of major birth defects compared to the general population comparator. Hum Reprod, 22 (9):2428-2436. The Korlym brand of mifepristone is a cortisol receptor blocker, used to manage and treat high blood glucose levels (hyperglycemia) in people with Cushing’s syndrome. Feb 1, 2022 · In a prospective study in France of 46 pregnancies exposed to a single dose of mifepristone alone and 59 pregnancies exposed to a single dose of mifepristone and misoprostol, the overall major birth defect rate (4%) was greater than the general population background rate of 2% to 3% (2 birth defects in each group). You might have heard people liken this to “taking an abortion pill These high-quality data provide evidence that mifepristone pretreatment is the optimal medical approach to women with missed miscarriage. The results show that progesterone can successfully reverse mifepristone in some cases, without increasing the risk of birth defects. ) (Ref 3) • In children who survive mifepristone poisoning and continue to birth, mifepristone alone has not been found to be associated with birth defects. TFMRs are also performed to save the mother’s life. The malformations included cranial nerve defects (especially pairs 6 and 7, characteristic of the Möbius syndrome) and various limb abnormalities. mifepristone or RU-486) and Cytotec (misoprostol). Mifeprex tablets each contain 200 mg of mifepristone, a synthetic steroid with antiprogestational effects. This class also includes Ella (ulipristal) and onapristone among others. Repeated medical abortions and the risk of preterm birth in the subsequent pregnancy. We included 297 women with anembryonic gestation or embryonic/fetal demise to receive misoprostol vaginally with or without mifepristone pretreatment; treatment success (complete pregnancy expulsion) rates with one misoprostol dose and mifepristone pretreatment (84%, 95% CI 77–90%) was higher than with misoprostol alone (67%, 95% CI 59–75%). Jun 13, 2024 · RU486 is a medication used to induce a miscarriage in a pregnancy less than 10 weeks along. Jul 17, 2019 · The abortion pill reversal protocol is done after the first medication, mifepristone, is given. Talk with your provider. Heavy bleeding, stomach pain, and fever after taking the medications can be signs of something more serious that requires medical attention. Medical abortion is typically considered a failure when a surgical procedure is performed to complete the abortion for any reason, including incomplete abortion, continuing (viable) pregnancy, hemorrhage, or patient request. Call your healthcare provider for medical advice about any side effects that Sep 1, 2023 · To become certified to dispense mifepristone, pharmacies must: (1) be able to receive Prescriber Agreement Forms by email and fax; (2) be able to ship mifepristone using a shipping service that Mar 28, 2023 · Warning. Mar 26, 2024 · Mifepristone is one of two pills commonly used in medication abortion, accounting for more than half of all U. By blocking progesterone, mifepristone (Mifeprex) prevents a pregnancy from continuing. Mifeprex is the first drug approved by Birth defects have been reported with a continued pregnancy after a failed pregnancy termination with MIFEPREX in a regimen with misoprostol. However, this risk is small: less than 10 in 1000. In animal reproduction studies, increased fetal losses were observed in mice, rats, and rabbits and skull deformities were observed in rabbits with administration of mifepristone at doses lower than the Read this MEDICATION GUIDE. There were 94 live births (90. The tablets include the inactive ingredients colloidal silica anhydrous, corn starch, povidone, microcrystalline cellulose, and Jul 6, 2024 · Getting an elective abortion involves making a personal choice to end a pregnancy. 53 The belief that an “abortive pill” will induce birth defects favored a search for the teratogenic effects of misoprostol and then the Mifepristone is an important agent for the treatment of miscarriage and fetal demise, improving successful resolution of the pregnancy loss. In those children who have survived after the mother has Jun 7, 2018 · Mifepristone is a 19-nor steroid that acts as a competitive progesterone-receptor antagonist and a glucocorticoid-receptor antagonist and primes the myometrium and cervix for prostaglandin May 22, 2024 · This is an expected part of passing the pregnancy. 48% probability of having a perfectly healthy baby, and at 40, the probability is 98. Liver disease—Use with caution. Most often, elective abortions don't cause fertility issues or problems with future pregnancies. (Similar application is used in chemotherapy with methotrexate followed by leukovorin rescue. 10 Approval came more than 15 years after approval in the United States and more Carrying a pregnancy to term after taking Mifeprex or misoprostol may cause birth defects or death of the baby. Misoprostol has 4 primary effects, including cytoprotection of the gastrointestinal mucosa, uterotonic properties, diarrhea, and May 27, 2024 · 8 min read. There are case reports of birth defects after mifepristone use during pregnancy. 31 2014, Delgado has found a 57% success rate with the Abortion Pill Reversal treatment. Buccally, sublingually, or vaginally The “abortion pill” is the common name in the United States for using two different medications — mifepristone and misoprostol — to end an early pregnancy. Neither mifepristone or progesterone is associated with birth defects. Today, based on high-quality evidence, mifepristone is also endorsed by leading medical authorities like the American College of Obstetricians and Gynecologists In those who continue pregnancy after use of mifepristone together with misoprostol for termination, birth defects may occur. In 2014, 31% of non-hospital induced abortions were medical The changes to the Mifepristone REMS Program include the following 4 5 : Permanent removal of the in-person dispensing requirement. It works in tandem with misoprostol. , 2013). Mifepristone may be dispensed in-person or by olloidal silica, maize starch, povidone, magnesium. At the age of 35, pregnant mothers can expect a 99. The abortion pill is very effective. Dr. You must agree to the abortion and surgery if needed. Mar 17, 2023 · There are no data that assess the risk of birth defects in women exposed to mifepristone during pregnancy. IUDs, however, can cause miscarriage and increases the In a prospective study in France of 46 pregnancies exposed to a single dose of mifepristone alone and 59 pregnancies exposed to a single dose of mifepristone and misoprostol, the overall major birth defect rate (4%) was greater than the general population background rate of 2% to 3% (2 birth defects in each group). First approved in 2000, Mifeprex blocks the Jan 23, 2024 · As the mother’s age increases, the incidence of serious or fatal birth defects rises, but still remains small. 48%. Dec 1, 2023 · Conclusion: Uterine rupture with mifepristone and misoprostol use during second-trimester induction abortion is rare, with the risk increased to 1% in individuals with prior cesarean birth. 3 days ago · A Termination for Medical Reasons (TFMR) is the ending of a pregnancy due to the diagnosis of a fetal defect. Mar 26, 2024 · In 1962, Congress further expanded the FDA’s authority after the drug thalidomide was shown to cause severe birth defects — this time, to require that drugs be proven effective. The optimum interval between mifepristone and misoprostol intake should be 24 to 48 hours (EL1, grade A). Kidney disease or. The Food and Drug Administration (FDA) approved mifepristone in 2000 as a safe and effective way to end a pregnancy. This is also known as a medically based or medically indicated termination. Jul 26, 2023 · Mifepristone (Mifeprex) is an antiprogestin medication. 001), respectively. Both of the abortion pills (Mifepristone and Misoprostol) are rapidly removed from the body, thus they do not have any effect on future pregnancies. In the uterus, coordinated myometrial cell contraction is not triggered by neural activation; instead Apr 7, 2023 · A federal judge in Washington State issued a ruling ordering the Food and Drug Administration to make no changes to the availability of the abortion pill mifepristone on Friday, directly Most infants born after exposure to mifepristone do not have birth defects. 2020 ). S. Condoms and other barrier birth control methods are safe to use in pregnancy. Hypokalemia (low potassium in the blood)—Should be corrected first before using this medicine. This involves taking medicine to end a pregnancy. The second pill, misoprostol, is usually taken one or two days after the first. The most common side effects reported of Mifeprex affecting 15% or more women are nausea, weakness, fever/chills, vomiting, headache, diarrhea, and dizziness. Conclusions: The reversal of the effects of mifepristone using progesterone is safe and effective. 1. Mifepristone administered to pregnant mice, rats, and rabbits during organogenesis caused pregnancy loss in all species at clinically relevant doses Jun 13, 2024 · June 13, 2024. In animal reproduction studies, increased fetal losses were observed in mice, rats, and rabbits and skull deformities were observed in rabbits with administration of mifepristone at Feb 28, 2024 · Mifepristone, also called RU-486, is a synthetic steroid with dual FDA-approved applications. May 29, 2023 · This birth defect rate is comparable to the 3 percent birth defect rate in the general population (Delgado et al. Mifegyne is available a. Firstly, it is utilized in combination with misoprostol for pregnancy termination up to 10 weeks of gestation, offering a medical alternative to surgical procedures for induced abortions. Methods: Women were included in the study when they or their doctors asked a French pharmacovigilance centre or the Paris Teratogen Information Service about the risk of mifepristone exposure in early pregnancy. The documented birth defect rate in ba-bies born after mifepristone reversal is 2. In 2020, Creinin published a randomized controlled trial designed to study the safety and efficacy of mifepristone antagonization using high-dose oral progesterone ( Creinin et al. Androgens and anabolic steroids Natural androgens: androsterone and testosterone Birth defects have been reported with a continued pregnancy after a failed pregnancy termination with Mifepristone tablets, 200 mg in a regimen with misoprostol. This study provides evidence for a possible option for women who change their mind after taking Apr 12, 2024 · Available data limited to exposure following a single dose of mifepristone during pregnancy showed a higher rate of major birth defects compared to the general population comparator (See Data). 4. This makes is hard to know if the reported birth An expert review of the teratogenicity of misoprostol was undertaken in 2002. In animal reproduction studies, increased fetal losses were observed in mice, rats, and rabbits and skull deformities were observed in rabbits with administration of mifepristone at Nov 11, 2019 · Researchers do not know, she said, whether the combination could cause birth defects, for example. Make sure that you know about this drug, what it is for, how to use it, and when to go back to your doctor. Mifepristone works by blocking the hormone progesterone. - Increase risk of birth defects if given in early pregnancy. Talk with your healthcare provider. Sep 23, 2022 · The largest prospective study of 46 women continuing a pregnancy after mifepristone resulted in eight miscarriages and, in the pregnancies that continued, two major malformations (5. The tablets are light yellow in color, cylindrical and biconvex, and are intended for oral administration only. orally Misoprostol dose/route 800 mcg. Misoprostol Mifepristone blocks a natural substance If the treatment fails and the pregnancy continues until birth, there is a risk of birth defects. Mar 24, 2023 · While less effective, some people only take misoprostol. If you decide Mifeprex is right for you, sign the PATIENT AGREEMENT. Mifepristone (Mifeprex) is a synthetic steroid used to terminate early pregnancy. Feb 19, 2024 · Misoprostol is exclusively approved by the US Food and Drug Administration (FDA) for the prevention and treatment of gastric ulcers induced by nonsteroidal anti-inflammatory drugs (NSAIDs) in patients who are taking NSAIDs and are at high risk for ulceration. 2011. a. 7%, compared to the generally quoted rate of 3% in the general population. Birth defects related to misoprostol exposure in pregnancy are poor growth of limbs (missing parts of finger/toes, or parts of arms/legs), Moebius syndrome (weakness or paralysis of the facial muscles), cleft lip and/or cleft palate (lip and or roof of mouth formed with a split), arthrogryposis (stiff joints), muscle weakness, and club foot May 26, 2023 · We would like to show you a description here but the site won’t allow us. After getting a physical exam, swallow 3 tablets of Mifeprex. Mifepristone administered to pregnant mice, rats, and rabbits during organogenesis caused pregnancy loss in all species at clinically relevant doses Jun 27, 2024 · The associated rate, 2. Consult your health care professional before breast-feeding. There is a chance that there may be birth defects if the pregnancy is not ended. The chance of birth defects if the pregnancy is not ended is unknown. abortions. Feb 24, 2015 · As of Dec. Elective termination of pregnancy was performed after the subsequent diagnosis of trisomy 21 in one case. Of the 223 women who have received progesterone, 127 cases succeeded, according to a fact sheet Cigarette smoke is linked with a higher chance of preterm delivery (birth before week 37) and low birth weight (weighing less than 5 pounds, 8 ounces [about 2500 grams] at birth). Children with Birth Defects Can Be Happy If you do not want to get pregnant after ending your pregnancy, you must start using birth control right away. stearate, microcrystalline cellulose. Studies show that babies saved through abortion pill reversal are no more likely to have birth defects than the rest of the general population. 11 Mifepristone is embryocidal or feticidal but not teratogenic, according to Practice the American College of Obstetrician Gy-necologists. Before 7 weeks LMP, the dose of 400 μg misoprostol should be given orally (EL1, grade A) eventually repeated after 3 hours if no bleeding occurs. Secondly, mifepristone is employed in managing and treating hyperglycemia associated with Cushing syndrome. - Liver dysfunction. Sample: Patients exposed to mifepristone during the first 12 weeks of pregnancy. Medical abortion protocols emphasize the importance of Abstract. Here's what's at stake : Shots - Health News The case could affect not just abortion access but oversight of the drug industry and the Using Mifepristone and Misoprostol to end a current pregnancy will not have any effect or cause birth defects [1] to a future pregnancy. However, if you find yourself pregnant, you should discontinue use and talk to your ob/gyn. Serious and sometimes fatal infections and bleeding occur very rarely. In most cases, the baby’s birth was eagerly anticipated, but the diagnosis of fetal anomalies is leading Is Abortion Pill Reversal Safe? Progesterone, used in the reversal process, has been safely used in pregnancy for more than 50 years. Common side It is important to note that that misoprostol exposure, which often occurs subsequently to mifepristone use, is independently associated with a spectrum of fetal abnormalities, including Möbius syndrome and limb reduction defects. The authors updated a Cochrane meta-analysis with their new data and showed a clear and statistical benefit of mifepristone pretreatment compared with misoprostol alone (RR 1·15, 95% CI 1·01–1·30). Misoprostol, a synthetic analog of prostaglandin E1, is currently used in Chile and other countries as an antiulcer medication, mainly for the prevention of non-steroidal anti-inflammatory-induced gastric ulcers. Side Effects . It works by blocking the activity of cortisol. Antiprogesterone: Mifepristone It is a competitive blocker of progesterone receptors. The more exposure to cigarette smoke that a person has during pregnancy, the greater the chance for preterm delivery and the earlier the baby could be born. In animal reproduction studies, increased fetal losses were observed in mice, rats, and rabbits, and skull deformities were observed in rabbits with administration of mifepristone at doses lower than the A novel estrogen-free oral contraceptive pill for women: multicentre, double-blind, randomized controlled trial of mifepristone and progestogen-only pill (levonorgestrel). Details of the full report are available here. There is no evidence that mifepristone causes birth defects. Discuss the benefits and risks of using Mifeprex to end your pregnancy. Jul 1, 2024 · Poor blood circulation—Mifeprex® causes heavy bleeding in a small portion of users, this may be intensified in patients with bleeding disorders. The mean number of adverse reactions per patient did not differ significantly between Mar 25, 2024 · The Supreme Court hears the mifepristone case Tuesday. 6%) miscarriages (including one with major malformation). 7%, is equal to the birth defect rate among the general population, which is approximately 3%. The report concluded that: “There is an association between birth defects and in utero exposure to misoprostol. Mifepristone is also available as another product (Mifeprex) that is used alone or in combination with another medication to end an early pregnancy. It is used with PGF2α to induce medical abortion in the first trimester. Liao H, et al. k. In general, it is used up to 70 days, or 10 weeks, after the first day of your last menstrual period. Similar Jul 7, 2022 · On its own, mifepristone may prevent a pregnancy from continuing and cause a miscarriage, but studies have shown that even in higher doses than now used in abortion care, many pregnancies continue and are not affected after the first tablet. Talk with your health care provider. 1, 3 x 1, 15 x 1 or 30 x 1 tablets. Apr 1, 2013 · Mifepristone can be taken at home (professional agreement). 5 to 78), and the diagnosis of neural-tube defects was made within 1 week of birth in most cases. In addition to clinics, medical offices, and hospitals, certified pharmacies can now dispense mifepristone to patients with a prescription from a certified prescriber. At 8-9 weeks pregnant, it works about 94-96% of the time. But risks to future pregnancies may depend on the type of elective abortion you have: Medical abortion. Mifepristone (MIF-e-PRIS-tone If the treatment fails and the pregnancy continues until birth, there is a risk of birth defects. Initial studies show that the birth defect rate in babies born after the APR is less than or equal to the rate in the general population. In 2014, 31% of non-hospital induced abortions were medical 1. It appears that the abortion process induced by misoprostol (e. III. 2018, 26). Mifepristone and misoprostol pass into breast milk. This monograph only gives information about mifepristone (Korlym) used to Feb 2, 2023 · Mifepristone is a safe and effective medication used for abortion. Before you take mifepristone, you should read the Medication Guide and you and your health care provider should discuss the benefits and risks of your using mifepristone tablets, 200mg. Cramping and bleeding are common abortion pill side effects that usually start within 2 to 24 hours of taking misoprostol. 0. If this drug does not cause a full abortion, surgery may be needed. yellow biconvex tablet, with a diameter of 11 mm with “167 B” engraved on one side. Exposure to a single large dose of mifepristone in newborn rats was not associated with any reproductive problems, although chronic low-dose exposure of newborn rats to mifepristone was associated with structural and surgical procedure to end your pregnancy. The abortion pill is unsuccessful approximately 5% to 10% of the time with the potential of requiring an additional surgical abortion procedure to complete the termination. If you’re taking mifepristone and misoprostol, it depends on how far along the pregnancy is, and how many doses of medicine you take: At 8 weeks pregnant or less, it works about 94-98% of the time. These are not all the possible side effects of Mifeprex. Jun 13, 2024 · Unintended use of hormonal birth control during early pregnancy carries a very low risk of birth defects or miscarriage. Without progesterone . An FDA-approved method of medical abortion, Mifeprex is used in combination with Cytotec (misoprostol). Uterine rupture has been reported when misoprostol was administered in pregnant women to induce labor or to induce abortion. However, mifepristone is often used in combination with another medication called misoprostol, which has been linked with birth defects. Mifepristone is in a class of medications called cortisol receptor blockers. Sources. The chemical abortion regimen consists of two drugs: Mifeprex (a. Jan 6, 2021 · In the mifepristone group, 80/133 (60•2%) patients reported at least one adverse reaction, which was significantly more than the 65/137 (47•7%) patients reporting an adverse reaction in the placebo group (p = 0•024, RR=1•27, 95% CI 1•01–1•59). Day 3 at your provider’s office: If you are still pregnant, take 2 misoprostol tablets. [17] Mifepristone blocks a natural substance If the treatment fails and the pregnancy continues until birth, there is a risk of birth defects. mifepristone. 18 2. To decrease the chance of birth defects, avoid getting pregnant again before your next menstrual period. 1 Protocol Summary for Medication Abortion with Mifepristone and Misoprostol Maximum gestational age 77 days from last menstrual period (LMP)2,3 Mifepristone dose 200 mg. it’s unlikely to cause birth defects Both mifepristone and misoprostol can cause birth defects if you are still pregnant. dj tq bn py co dm tj ok vp pj