Comparative dissolution profile of paracetamol. Chemically, it is 4-hydroxy acetanilide (acetaminophen).
Comparative dissolution profile of paracetamol In this study, nine different paracetamol tablet dosage forms available on the Turkish Drug Market have been investigated and physical controls were realized. Arti cle Info : Received 18 Nov 201 9; Review Completed 1 3 Dec 2019; Accepted 20 Dec 2019; Availabl e online Dissolution can best be described as a tool that can provide valuable information about the availability of a drug product. It is a widely used over-the-counter analgesic and antipyretic. form. A comparative study of the in-vitro dissolution profiles of paracetamol and caffeine combination , Y. G. . Paddle and rotati … Figure 1: Comparative in vitro dissolution profiles of paracetamol tablets Dissolution studies can give an idea of the amount of drug available absorption after oral administration. The study was conducted to assess the comparative in-vitro quality control parameters through the evaluation of weight variation, hardness, friability, disintegration time and dissolution profile between the KEYWORDS: Paracetamol, Comparative, Quality control parameters, Evaluation INTRODUCTION Paracetamol or acetaminophen is active metabolites of Phenacitin. Drugs with poor dissolution profiles will not be available in the body system or target organ/tissues to elicit therapeutic effect. M. Bioavailability and absorption of drug is dependent on dissolution profile. A dissolution study gives an idea about the amount of drug available for absorption after oral administration. Paracetamol is approved for reducing fever in people of all ages. In the present study, the release of paracetamol from all tablets, specially F – C batch (Crocin 500) was followed sustained release; though the drug Paracetamol is a widely used non-prescription analgesic and antipyretic medicine. Chemically, it is 4-hydroxy acetanilide (acetaminophen). Zayed ABSTRACT Dissolution testing is an in vitro technique of great importance in formulation and development of pharmaceutical dosage forms, as it can be used as a substitute for in vivo studies Jan 15, 2020 ยท Keywords: Paracetamol, Mark eted Tablet, In-Vitro dissolution study, Rele ase profile. Issaand A. rlrbmvzwwjjexgthnvvstlwcvfhiyccgwrjwwmyyfpkcfxljtjj